Measuring what matters in sleep disorder trials: A guide to COA selection
Sleep disorders are a growing global health burden. Conditions like insomnia affect an estimated 852 million adults worldwide, and obstructive sleep apnea affects an estimated 936 million adults globally. These, along with other conditions such as restless legs syndrome, narcolepsy, and REM sleep behavior disorders, influence energy levels, concentration, emotional well-being, daily activities, work productivity, and overall quality of life.
Though traditional sleep assessments help researchers understand what happens during sleep, physiological measures do not capture how patients feel and function during the day. Which is why researchers use Clinical Outcome Assessments to understand the patient's lived experience and assess whether treatment is making a difference in everyday life.
Mapi Research Trust's new guide, Measuring What Matters in Sleep Disorders, explores:
- Why patient-centered outcomes matter in sleep trials
- Current regulatory expectations for COA selection
- Key instruments used across insomnia, OSA, narcolepsy, RLS, and RBD research
- How to build a fit-for-purpose endpoint strategy that reflects what matters most to patients
If you're designing a sleep study or refining your endpoint strategy, this guide offers a practical overview of the COAs and measurement approaches to help researchers better understand treatment benefit.